Basal EFNA3 Facilitates Luminal-Driving Mammary Epithelial Migration and Cancer Metastasis by Promoting OXPHOS

Chen J, Ma R, Feng D, Deng Z, Lu Y, Xia K, Klein O, Lu P. bioRxiv. 2024 Oct 21. doi: https://doi.org/10.1101/2024.10.17.618667

 

 

Mammary Epithelial Migration is EMT-Independent

Chen J, Ma R, Deng Z, Lu Y, Zhou J, Xia K, Klein O, Lu P. bioRxiv. 2024 Oct 17, 2024. doi: https://doi.org/10.1101/2024.10.17.618667

 

 

 Tight Junction Component Occludin Binds to FIP5 to Regulate Endosome Trafficking and Mitotic Spindle Function.

Zhang Z, Chen J, Ma R, Xu C, Lu Y, Zhou J, Xia K, Lu P.  Adv Sci (Weinh). 2024 Aug;11(30):e2308822. doi: 10.1002/advs.202308822. Epub 2024 Jun 17. PMID: 38884279; PMCID: PMC11321699.

 

 

 

Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop. 

Ma R, Feng D, Chen J, Zhou J, Xia K, Kong X, Hu G, Lu P. Adv Sci (Weinh). 2024 May 6:e2307452. doi: 10.1002/advs.202307452. Epub ahead of print. PMID: 38708713.

 

  

Sprouty genes regulate activated fibroblasts in mammary epithelial development and breast cancer. 

Li J, Ma R, Wang X, Lu Y, Chen J, Feng D, Zhou J, Xia K, Klein O, Xie H, Lu P. Cell Death Dis. 2024 Apr 10;15(4):256. doi: 10.1038/s41419-024-06637-2. PMID: 38600092

 

 

Cytoophidia couple adipose architecture and metabolism. 

Liu J, Zhang Y, Zhou Y, Wang QQ, Ding K, Zhao S, Lu P, Liu J, Cellular and Molecular Life Sciences. 2022 Oct 1;79(10):534.

 

 

LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland. 

Ma R, Gong D, You H, Xu C, Lu Y, Bergers G, Werb Z, Klein OD, Petritsch CK, Lu P. Cell Rep. 2022 Feb 15;38(7):110375. PMID: 35172155.

 

 

Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR.

Lu Y, Zhou T, Xu C, Wang R, Feng D, Li J, Wang X, Kong Y, Hu G, Kong X, Lu P. PLoS Biol. 2022 Jan 18;20(1):e3001518.PMID: 35041644

 

 

Born to Run? Diverse Modes of Epithelial Migration.

Lu P, Lu Y. Front Cell Dev Biol. 2021 Aug 12;9:704939. PMID: 34540829

 

 

Asymmetric Stratification-Induced Polarity Loss and Coordinated Individual Cell Movements Drive Directional Migration of Vertebrate Epithelium.

Lu Y, Deng R, You H, Xu Y, Antos C, Sun J, Klein OD, Lu P. Cell Rep. 2020 Oct 13;33(2):108246. PMID: 33053348

 

 

Capturing RNA-protein interaction via CRUIS.

Zhang Z, Sun W, Shi T, Lu P, Zhuang M, Liu JL. Nucleic Acids Res. 2020 May 21;48(9):e52. PMID: 32140725

 

 

Occludin protects secretory cells from ER stress by facilitating SNARE-dependent apical protein exocytosis.

Zhou T, Lu Y, Xu C, Wang R, Zhang L, Lu P. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4758-4769. PMID: 32051248

 

 

Quantitative Phosphoproteomics Reveals System-Wide Phosphorylation Network Altered by Spry in Mouse Mammary Stromal Fibroblasts.

Shi T, Yao L, Han Y, Hao P, Lu P. Int J Mol Sci. 2019 Oct 30;20(21):5400. PMID: 31671542

 

 

Mammary stem cells, where art thou? 

Lu P, Zhou T, Xu C, Lu Y. Wiley Interdiscip Rev Dev Biol. 2019 Nov;8(6):e357. PMID: 31322329.

 

 

A 3D Fibroblast-Epithelium Co-culture Model for Understanding Microenvironmental Role in Branching Morphogenesis of the Mammary Gland. 

Koledova Z, Lu P. Methods Mol Biol. 2017;1501:217-231. PMID: 27796955.

 

 

Melatonin Suppresses Toll Like Receptor 4-Dependent Caspase-3 Signaling Activation Coupled with Reduced Production of Proinflammatory Mediators in Hypoxic Microglia.

Yao L, Lu P, Ling EA. PLoS One. 2016 Nov 3;11(11):e0166010. PMID: 27812200

 

 

SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.

Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5731-40. PMID: 27621461

 

 

The Role of Stroma in Tumor Development.

Werb Z, Lu P. Cancer J. 2015 Jul-Aug;21(4):250-3. PMID: 26222075

 

 

FGF ligands of the postnatal mammary stroma regulate distinct aspects of epithelial morphogenesis.

Zhang X, Martinez D, Koledova Z, Qiao G, Streuli CH, Lu P. Development. 2014 Sep;141(17):3352-62. Epub 2014 Jul 30. PMID: 25078648

 

 

Modulation of fibroblast growth factor signaling is essential for mammary epithelial morphogenesis.

Zhang X, Qiao G, Lu P. PLoS One. 2014 Apr 9;9(4):e92735. PMID: 24718286

 

 

Stromal regulation of embryonic and postnatal mammary epithelial development and differentiation.

Howard BA, Lu P. Semin Cell Dev Biol. 2014 Jan-Feb;25-26:43-51. PMID: 24445189

 

 

Pleiotropic functions of fibroblast growth factor signaling in embryonic mammary gland development. 

Kim EJ, Jung HS, Lu P. J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):139-42. PMID: 23613170

 

 

The extracellular matrix: a dynamic niche in cancer progression.

Lu P, Weaver VM, Werb Z. J Cell Biol. 2012 Feb 20;196(4):395-406. PMID: 22351925

 

 

Extracellular matrix degradation and remodeling in development and disease.

Lu P, Takai K, Weaver VM, Werb Z. Cold Spring Harb Perspect Biol. 2011 Dec 1;3(12):a005058. PMID: 21917992

 

 

Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis.

Lu P, Ewald AJ, Martin GR, Werb Z. Dev Biol. 2008 Sep 1;321(1):77-87. PMID: 18585375

 

 

The apical ectodermal ridge is a timer for generating distal limb progenitors. 

Lu P, Yu Y, Perdue Y, Werb Z. Development. 2008 Apr;135(8):1395-405. PMID: 18359901

 

 

 

Comparative mechanisms of branching morphogenesis in diverse systems. 

Lu P, Sternlicht MD, Werb Z. J Mammary Gland Biol Neoplasia. 2006 Oct;11(3-4):213-28. PMID: 17120154

 

 

Hormonal and local control of mammary branching morphogenesis.

Sternlicht MD, Kouros-Mehr H, Lu P, Werb Z. Differentiation. 2006 Sep;74(7):365-81. PMID: 16916375.

 

 

Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function.

Lu P, Minowada G, Martin GR.Development. 2006 Jan;133(1):33-42. PMID: 16308330.